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Kaplan-Meier curves for overall survival (A) and progression-free survival (B), the Sarcoma Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care, the Members of the Sarcoma Disease Site Group of Cancer Care Ontario's Program in Evidence-Based Care. Although some older patients can tolerate intensive combination treatment, the regimen we used is very myelosuppressive, therefore our data cannot be extrapolated to patients older than 60 years. © 2021 NFL Enterprises LLC. MB), Help with It is highly recommended that you use the latest versions of a supported browser in order to receive an optimal viewing experience. image, http://www.eortc.be/services/download/Protocols/62012.pdf, Download .pdf (.1 © 2014 Elsevier Ltd. All rights reserved. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. CF, PCWH, APdT reviewed cases and reviewed the report. pdf files, The Lancet Regional Health – Western Pacific, Intercurrent death not a result of malignant disease, Progression of disease or death caused by progressive disease, Patient's refusal (not related to toxic effects), Intercurrent death (not related to malignant disease or toxic effects). Effective targeted treatment is unavailable for most sarcomas and doxorubicin and ifosfamide—which have been used to treat soft-tissue sarcoma for more than 30 years—still have an important role. The browser you are using is no longer supported on this site. Alex Perez first appeared on November 29, 2000, later becoming the fiancée of Malcolm Winters and lover of his brother, Neil.The role, portrayed by Alexia Robinson, was created to fill the void left by Victoria Rowell. This study only recruited patients up to age 60 years. By Chris Arrant . Additionally, because overall survival was the primary endpoint, any possible bias in assessment of response or progression-free survival was thought to be of lesser importance. NFL footage © NFL Productions LLC. To update your cookie settings, please visit the, https://doi.org/10.1016/S1470-2045(14)70063-4, Doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue sarcoma: a randomised controlled phase 3 trial, View Large How can these data be used to guide clinical practice? NFL and the NFL shield design are registered trademarks of the National Football League.The team names, logos and uniform designs are registered trademarks of the teams indicated. Handbook for reporting results for cancer treatment. Watch game, team & player highlights, Fantasy football videos, NFL event coverage & more Dose-intensive chemotherapy with growth factor or autologous bone marrow/stem cell transplant support in first-line treatment of advanced or metastatic adult soft tissue sarcoma: a systematic review. Conversely, if acute symptoms are best relieved by tumour shrinkage, the use of combination treatment would be justified; likewise, if chemotherapy is being given before surgery or radiotherapy, then combination treatment could be used to debulk the tumour. Imatinib mesylate in advanced dermatofibrosarcoma protuberans: pooled analysis of two phase II clinical trials. Long-term results of a multicenter SAKK trial on high-dose ifosfamide and doxorubicin in advanced or metastatic gynecologic sarcomas. The results of our study are important in relation to other studies comparing doxorubicin with a combination of doxorubicin and an alkylating drug, for example, a phase 3 trial of palifosfamide, the results of which were presented at the European Cancer Congress 2013 (. PICASSO 3: a phase 3 international randomized double blind placebo-controlled study of doxorubicin plus palifosfamide vs. doxorubicin plus placebo for patients in first-line for metastatic soft tissue sarcoma. We use cookies to help provide and enhance our service and tailor content and ads. As in most previous studies, combination treatment was significantly more toxic than the single-drug regimen, but there was no excess of toxic deaths. The destination for all NFL-related videos. Clinical situations might also exist for which delaying disease progression for as long as possible is the priority; for example, if adjacent critical structures such as nerves are involved. Doxorubicin was shown to have activity against soft-tissue sarcomas in 1969. This study was supported by a donation from Cancer Research UK through the EORTC Charitable Trust. The proportion of patients who had a response in both groups was lower than reported in some—but not all—previous EORTC studies. Image, Download Hi-res The EORTC received financial support from Amgen for the cost of pegfilgrastim. 8 month improvement in median progression-free survival with the dose-intensified regimen, and a greater proportion of patients responded to the combination therapy than to doxorubicin alone. Prognostic and predictive factors for outcome to first-line ifosfamide-containing chemotherapy for adult patients with advanced soft tissue sarcomas: an exploratory, retrospective analysis on large series from the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG). Prior to her debut, the character was only known as "Erin". The 39-year-old was up 4-2 in the final set against world number 75 Pablo Andujar of Spain but lost the next four games to lose 6-4 4-6 6-4 in his … High-dose chemotherapy consolidation for chemosensitive advanced soft tissue sarcoma patients: an open-label, randomized controlled trial. These data should also be considered in the context of the diversification of chemotherapy and other systemic treatment that is taking place in the management of soft-tissue sarcoma. We thank Anne Kirkpatrick and the other staff at EORTC headquarters who contributed to the success of the trial. Results of randomised studies of the EORTC Soft Tissue and Bone Sarcoma Group (STBSG) with two different ifosfamide regimens in first- and second-line chemotherapy in advanced soft tissue sarcoma patients. However, we deemed the cost and practical implications of having an intravenous ifosfamide plus mesna matching placebo to be too great. CH, SL, and SM work at EORTC on project management and statistical support. IJ wrote the protocol, reviewed all the case record forms for eligibility and protocol violations, recruited patients, and wrote and edited the report with SL. JV, HG, JTH, PS, J-YB, JMK, JS, JW, PH, AK-H, TA, and WTAvdG recruited patients, and reviewed and revised the report. The Lancet Regional Health – Western Pacific, Advancing women in science, medicine and global health, for the European Organisation and Treatment of Cancer Soft Tissue and Bone Sarcoma Group, Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data, Rituximab versus a watch-and-wait approach in patients with advanced-stage, asymptomatic, non-bulky follicular lymphoma: an open-label randomised phase 3 trial, the European Organisation for Research and Treatment of Cancer Soft Tissue, the EORTC Soft Tissue and Bone Sarcoma Group, the Swiss Group for Clinical Cancer Research. The following browsers are supported: Chrome, Edge (v80 and later), Firefox and Safari. All other NFL-related trademarks are trademarks of the National Football League. Progression-free rate as the principal end-point for phase II trials in soft-tissue sarcomas. All authors reviewed the final version of the report. If palliative chemotherapy is being given to control metastatic—typically pulmonary—disease, rather than to relieve acute symptoms, then sequential single-drug chemotherapy will probably be less toxic without significantly impairing survival. Individual sarcoma subtypes are being treated increasingly differently; for instance, paclitaxel for angiosarcoma. We are grateful to all the patients who took part, and their relatives, and thank the participating centres who worked on the study, including P Woll (Weston Park Hospital, Sheffield, UK), D Stark and M Marples (St James's Hospital, Leeds, UK), M Leahy (Christie Hospital, Manchester, UK), R D Issels and L Lindner (Klinikum der Universität München, Munich, Germany), M Verrill (Newcastle General Hospital, Newcastle-upon-Tyne, UK), C M Wendtner (University of Cologne, Cologne, Germany), V Gruenwald (Med Hochsch Hannover, Hannover, Germany), G Folprecht (Universitätsklinikum Carl Gustav Carus, Dresden, Germany), A K L Reynders (University Medical Center Groningen, Groningen, Netherlands), T Gil (Hôpital Universitaire, Bordet-Erasme, Brussels, Belgium), I Hennig (Nottingham General Hospital, Nottingham, UK), F Cowie and J D White (Gartnavel General Hospital, Glasgow, UK), O S Nielsen (Aarhus University Hospital, Aarhus, Denmark), J Vermorken and J Van Den Brande (The Antwerp University Hospital, Antwerp, Belgium), S Leyvraz (CHU Vaudois, Lausanne, Switzerland), J Baselga (Hospital de Vall d'Hebron, Barcelona, Spain), A Casado Herraez (San Carlos University Hospital, Madrid, Spain), D Cameron (Western General Hospital, Edinburgh, UK), D Spooner (Queen Elisabeth Hospital, Birmingham, UK), S Bauer (University of Duisburg-Essen, Essen, Germany), S Rorke (Dr Bliss Murphy Centre, St John's, NL, Canada), R Tozer (Juravinski Cancer Centre, Hamilton, ON, Canada), J-W Henning (South Medical Clinic, Calgary, AB, Canada), G Mechtersheimer (Universitätsklinik Heidelberg, Heidelberg, Germany), S Daugaard (University of Copenhagen, Copenhagen, Denmark), R Sciot (UZ Leuven, Leuven, Belgium), and F Collin (CGFL Dijon, Dijon, France). Harvey Lawrence Pekar (/ ˈ p iː k ɑːr /; October 8, 1939 – July 12, 2010) was an American underground comic book writer, music critic, and media personality, best known for his autobiographical American Splendor comic series. Although more toxic than single drug, the combination did seem safe, at least for this age group. Meta-analysis of ifosfamide-based combination chemotherapy in advanced soft tissue sarcoma. We acknowledge NHS funding to the Royal Marsden/ICR National Institute for Health Research Biomedical Research Centre and researchers at the NIHR University College London Hospital's Biomedical Research Centre. The Nightwing that almost was - inside the 2014 proposal by James Tynion IV and Mikel Janín. The contribution of NCIC Clinical Trials Group was supported by the Canadian Cancer Society Research Institute ( grant 021039 ). The study was not masked, which might have biased the assessment of response and disease progression. 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